Mice Fail as Models of Human Inflammation
Leaving the mice alone and testing drugs on human cells appears preferable.
Writing in the Proceedings of the National Academy of Sciences, the researchers analyzed data from human burn patients and those suffering blunt trauma and sepsis, as well as those with other inflammatory conditions, which could include diseases contributing to neck pain. The findings suggest that research on mice has been deceiving scientists for years, leading to approval of drugs that have little, or no merit in human patients and which may actually be unsafe.
The authors note that “New approaches need to be explored to improve the ways that human diseases are studied.” One way would be by using research models for drug development. Next time anti-inflammatory pain medications are prescribed for your neck pain, you may wish to check if a mouse had them first.
Reference
Seok J, Warren HS, Cuencac AG, et al. Genomic responses in mouse models poorly mimic human inflammatory disease. PNAS. Published online before print February 11,2013.
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The article highlights various reasons supporting this claim, including differences in the immune response, genetic variations, and physiological discrepancies between mice and humans. The research mentioned in the article emphasizes the need for improved methods of studying inflammation that consider the complexities of human biology and can provide more reliable results.
The author discusses the limitations and discrepancies associated with using mice as models for studying inflammation in humans. Notably, the author highlights the key factors that contribute to the inadequacy of mice in accurately representing human inflammatory responses. Furthermore, the article delves into the intricate biological differences between mice and humans, such as variations in immune system components and genetic makeup, which further impede the translation of findings from preclinical mouse studies to effective clinical therapies for humans.
The comment intelligently brings up the inherent genetic and physiological differences between mice and humans, emphasizing the need for alternative research methods to better understand human-specific inflammatory processes. Additionally, the commenter mentions the importance of acknowledging the shortcomings of using mice models, as relying solely on them may lead to misleading outcomes and hinder the development of effective treatments for human inflammatory disorders.
The author also points out that relying solely on mice for inflammation research may lead to misleading results and hinder the development of effective treatments for human inflammatory diseases. Ultimately, the article calls for a more cautious and comprehensive approach in biomedical research, emphasizing the importance of utilizing multiple models, including human-based systems, to bridge the gap between animal and human physiology and improve the understanding and treatment of inflammation.
The commenter argues that relying solely on mouse studies may not accurately reflect the inflammatory response in humans, potentially leading to misleading or ineffective treatments. They emphasize the need for more comprehensive research methods that incorporate human subjects and the importance of considering individual variations in immune responses.
The commenter argued that while there are inherent differences between mice and humans, such as their anatomy and genetic makeup, mice-based research has provided valuable insights into various aspects of inflammation and played a vital role in pharmaceutical development.
The author astutely points out that although prevalent in scientific research, mice may not accurately represent the complex inflammatory responses seen in humans. This notion sheds light on the necessity for alternative models or approaches to study human-specific inflammation, ultimately pushing the boundaries of our understanding in this field.
They emphasized the importance of bridging the gap between preclinical research and clinical applications to better understand and address the complexities of human inflammation.
The user highlights that while mice are commonly used in research to study various diseases and conditions, their responses do not always reflect those of humans. They argue that this discrepancy can lead to misleading results and ineffective treatments when translated to human patients.
The user’s comment serves as a valuable reminder that while mice have been widely used in biomedical research, caution must be exercised in generalizing findings from mouse studies to human conditions characterized by inflammation.
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