NSAIDs Double the Risk of Dangerous Blood Clots
Using NSAIDs to manage chronic neck pain could almost double your risk of venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism, according to new research published in the journal Rheumatology. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a popular prescription and over-the-counter remedy for relief of inflammation and pain but these drugs are far from safe, especially when used for chronic conditions.
The new meta-analysis looked at published observational studies in order to assess the association between NSAID use and these dangerous types of blood clot. Six studies met their inclusion criteria, with 21,401 VTE events assessed. The researchers, working at the Bassett Medical Center and Columbia University College of Physicians and Surgeons, New York City, found that a statistically significantly increased VTE risk among NSAID users and noted that physicians should be aware of this increased risk, especially if prescribing NSAIDs to people whose risk of dangerous blood clotting is already high.
Double the Risk of Potentially Fatal Blood Clots
Venous thromboembolism (VTE) is, thankfully, relatively rare, which is why these researchers had to use observational studies (VTE occurs rarely in clinical trials). They included 1 cohort study involving 19,293 people and 215 VTEs, and 5 case-control studies involving 21,186 cases, along with 110,824 controls. Studies took place in the United Kingdom, France, the Netherlands, Denmark, and Sweden between 2007 and 2013.
Compared to non-users of NSAIDs, users had a 1.8-fold risk of venous thromboembolism. Those using selective cyclooxygenase 2 (COX-2) inhibitors had a 1.99-fold risk. COX-1 inhibitors, like aspirin, have actually been seen to effectively prevent VTE, so the increased risk of this potentially fatal complication likely stems from the use of COX-2 inhibitors.
How COX-2 Inhibitors Work
COX-2 inhibitors prevent the synthesis of prostacyclins but stimulate thromboxane release. Prostacyclins are potent inhibitors of platelet activation and thromboxanes are potent facilitators of platelet aggregation in active platelets.
The potential for adverse events with the use of COX-2 inhibitors has actually been known for many years. In fact, rofecoxib (commonly known as Vioxx) was removed from the market in 2004 because research revealed a significant increase in heart attacks and strokes in those taking this particular NSAID. Other NSAIDs such as celecoxib have since had to display warnings on their labels regarding the risk of stroke and heart attack.
The benefits of COX-2 inhibitors for pain from conditions such as arthritis have been well documented in clinical trials, but the potential doubling of the risk of blood clots may have people with chronic pain conditions thinking twice about using celecoxib and rofecoxib.
Natural Pain Relief
Alternative pain relief options do exist, including natural inhibitors of COX-2 enzymes that do not appear to increase the risk of VTE when taken at their recommended dosage (although further study is certainly warranted to get a clearer picture of this risk).
Such ‘natural NSAIDs’ include:
- Turmeric (or, rather, curcumin, a compound found in turmeric)
- Thunder God Vine
- Omega 3 fatty acids (from fish oil, algal oil and flaxseed oil)
- Resveratrol (a phytochemical found in red grape skins)
- Genistein (an isoflavone found in soybeans)
- Quercetin (found in apples, garlic, onions and other plants)
Excessive consumption of fish (more than 46g a day) does appear to increase the risk of stroke, but at lower doses omega 3 from fish oil actually reduces the risk of stroke while offering relief from pain and inflammation. Curcumin and resveratrol appear to thin the blood and reduce platelet aggregation, thereby reduce the risk of blood clots and stroke. These natural pain relief products could, however, increase the risk of problematic bleeding and should be discontinued at least a week prior to elective surgery.
NSAIDs may remain popular for treating chronic neck pain and other pain conditions but they are typically contraindicated after surgery involving fusion as they can decrease healthy bone growth. They also pose a risk of liver damage and gastrointestinal upset. Anyone using NSAIDs such as celecoxib for chronic neck pain should consult their physician to discuss alternative options if they are concerned about the risk of dangerous blood clots and stroke.
Reference
Ungprasert P, Srivali N, Wijarnpreecha K, Charoenpong P, Knight EL. Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis. Rheumatology (Oxford). 2014 Sep 24. pii: keu408. [Epub ahead of print]
That is a really good tip particularly to those fresh to the blogosphere.
Simple but very precise info… Thank you for sharing this one.
A must read article! aid for ukraine
I think this is among the most significant information for
me. And i am glad reading your article. But wanna remark on some general things,
The website style is wonderful, the articles
is really nice : D. Good job, cheers aid ukraine
https://drwithoutdoctorprescription.site/ canadian pharmacy online
cialis and viagra mix generic version of cialis
canadian drugstore online buy prescription drugs online
https://drwithoutdoctorprescription.site/ ed meds online without prescription or membership
best non prescription ed pills buy prescription drugs from canada
cialis with effexor generic tadalafil 20mg india
viagra without a doctor prescription buy viagra online usa
https://sildenafilmg.shop/# viagra cost
buy real viagra online cheap viagra online
order viagra online viagra amazon
https://sildenafilmg.shop/# cost of viagra
buy real viagra online viagra over the counter walmart
mexican viagra cost of viagra
over the counter viagra order viagra online
viagra for men 100mg viagra
viagra from india sildenafil
buy doxycycline doxycycline nz
how to buy zithromax online zithromax pill
can i buy 40mg doxycycline online doxycycline 150 mg tablets
https://zithromaxforsale.shop/# zithromax capsules 250mg
doxycycline for sale online uk where to buy doxycycline over the counter
amoxicillin 250 mg capsule amoxicillin 500 mg price
https://buylipitor.store/# lipitor tabs
https://buylipitor.store/# lipitor tablets 10mg price
metformin 500 mg without prescription metformin tablets where to buy
https://buytadalafil.men/# buy tadalafil online paypal
https://cipro.best/# buy cipro online canada
diflucan 6 tablets diflucan 100 mg tablet
Лучшие фильмы в жанре боевик на ГидОнлайн..
Фильм смотреть онлайн в хорошем качестве бесплатно фильмы.
Смотреть онлайн фильмы и сериалы
https://gabapentin.icu/# neurontin 800 mg cost
ciprofloxacin 500mg buy online where can i buy cipro online
neurontin 400 mg capsule buy neurontin online
diflucan discount diflucan 200 mg daily
https://withoutprescription.store/# buy canadian drugs
Поиск фильмов, новости кино, отзывы пользователей..
Доступ сматреть кено.
Смотреть фильмы онлайн бесплатно
в хорошем HD.
diflucan 150 mg daily diflucan 150 mg tablet
https://gabapentin.icu/# gabapentin generic
новини київ
magnificent publish, very informative. I’m wondering why the opposite specialists of this sector do not realize this. You must proceed your writing. I am confident, you have a great readers’ base already!
ed treatments buy ed pills
ed meds online without doctor prescription best otc ed pills
https://erectionpills.best/# erectile dysfunction medicines
neurontin 204 neurontin 300 mg coupon
https://erectionpills.best/# new ed treatments
Психолог онлайн. Консультация Когда необходим прием психолога? – 7846 врачей,
7620 отзывов.
Популярные фильмы онлайн..
Здесь Фільм Бетмен (2022) онлайн українською мовою в HD.
У нас Только лучшие Фильмы интернета Бесплатно!
stat
https://doxycyclineonline.store/# buy doxycycline
best pills for ed ed pills for sale
stat
ed meds online without doctor prescription medication for ed dysfunction
doxycycline buy doxycycline
Ukraine
https://drugsonline.store/# erectile dysfunction medication
best ed pills online ed pills for sale
фильмы онлайн смотреть бесплатно
сериалы тут смотреть онлайн
https://edpills.best/# ed pill
ed drug prices pain medications without a prescription
https://doxycyclineonline.store/# doxycycline without prescription
doxycycline doxycycline for sale
natural ed medications non prescription ed pills
руторг новый адрес
stromectol 3 mg tablets price stromectol for humans for sale
https://stromectoltrust.com/# order stromectol over the counter
stromectol 12 mg tablets stromectol 12 mg tablets
stromectol stay active stromectol 3mg tablets
ivermectin dosage for rabbits stromectol tab 3mg
Лучше звоните Солу 5 сезон 9 серия смотреть онлайн
https://stromectoltrust.com/# stromectol 12 mg tablets
cure ed ed tablets
site
https://pharmacyizi.com/# ed drugs over the counter
Мир Дикого Запада 4 Сезон 4 Серия
https://pharmacyizi.com/# cheap erectile dysfunction pills
смотреть в хорошем качестве
site
https://pharmacyizi.com/# cheap ed drugs
https://pharmacyizi.com/# drugs online
pills for erection what causes ed
buy generic ed pills online treatment for erectile dysfunction
https://pharmacyizi.com/# best ed solution
https://pharmacyizi.com/# impotence pills
https://pharmacyizi.com/# best ed drugs
best ed medication ed drugs online from canada
https://pharmacyizi.com/# ed remedies
смотреть художественные фильмы
https://pharmacyizi.com/# ed natural treatment
best ed medicine natural herbs for ed
discount prescription drugs buy prescription drugs from canada cheap
https://allpharm.store/# Pamelor
тв фильмы
buying ed pills online ed drugs list
https://onlinepharmacy.men/# online pharmacy meds
Keflex Dostinex
medstore online pharmacy good pill pharmacy
https://erectionpills.shop/# medication for ed
new ed treatments medication for ed
Под напряжением 23 серия смотреть новинки фильмов в HD онлайн
ed treatment drugs drugs for ed
Тобол 2022 смотреть онлайн в хорошем качестве
https://allpharm.store/# canada online pharmacies
men’s ed pills п»їerectile dysfunction medication
Aurogra rx pharmacy
meds online without doctor prescription prescription drugs online
https://erectionpills.shop/# ed pills comparison
legitimate canadian pharmacy online reliable canadian pharmacy
Biaxin Top Avana
https://canadiandrugs.best/# canadian drug prices
https://canadiandrugs.best/# cvs prescription prices without insurance
https://stromectolbestprice.com/# how much ivermectin to give a dog
stromectol tablets buy online stromectol covid
is ivomec the same as ivermectin ivermectin for hookworm in humans
https://stromectolbestprice.com/# ivermectin pills for lice
stromectol tablets stromectol purchase
http://stromectolbestprice.com/# topical ivermectin for cats
site
https://drugsbestprice.com/# treat ed
buy prescription drugs without doctor buy erection pills
https://drugsbestprice.com/# herbal ed
Хатико Самый верный друг смотреть фильмы онлайн
https://medrxfast.com/# ed meds online without doctor prescription
best canadian online pharmacy prescription drugs
buy cheap prescription drugs online meds online without doctor prescription
https://medrxfast.com/# meds online without doctor prescription
prescription drugs without prior prescription carprofen without vet prescription
site
https://medrxfast.com/# buy prescription drugs without doctor
site
https://medrxfast.com/# prescription drugs without doctor approval
cat antibiotics without pet prescription buy prescription drugs online legally
https://medrxfast.com/# buy prescription drugs from canada cheap
https://medrxfast.com/# best online canadian pharmacy
best non prescription ed pills buy prescription drugs from canada cheap
https://medrxfast.com/# ed meds online without prescription or membership
https://medrxfast.com/# legal to buy prescription drugs from canada
https://medrxfast.com/# buy prescription drugs from canada
https://medrxfast.com/# canadian drugstore online
https://medrxfast.com/# meds online without doctor prescription
site
https://medrxfast.com/# canadian online drugstore
https://gabapentin.top/# 600 mg neurontin tablets
https://diflucan.life/# diflucan 150 mg fluconazole
site
https://gabapentin.top/# neurontin brand name
вусик джошуа коли бій 2022
https://diflucan.life/# how to buy diflucan
https://diflucan.life/# canadian order diflucan online
https://valtrex.icu/# buy valtrex generic online
воскресный вечер с владимиром соловьевым смотреть бесплатно последний выпуск вчера онлайн на ютубе
Дім дракона дивитись онлайн
https://paxil.tech/# paxil for bipolar
https://glucophage.top/# metformin order canada
воскресный вечер с владимиром соловьевым последний выпуск сегодня
https://deltasone.icu/# purchase prednisone no prescription
https://deltasone.icu/# 5 mg prednisone daily
https://deltasone.icu/# prednisone 15 mg daily
https://glucophage.top/# metformin glucophage xr
https://deltasone.icu/# brand prednisone
order prednisone 10 mg tablet prednisone uk over the counter
https://deltasone.icu/# generic prednisone 10mg
I discovered your blog site on google and check a few of your early posts. Continue to keep up the very good operate. I just additional up your RSS feed to my MSN News Reader. Seeking forward to reading more from you later on!…
It’s very interesting! If you need help, look here: hitman agency
Thank you for great information. look forward to the continuation. – womens hey dudes
Scrap metal grading standards Ferrous metal market dynamics Iron scrap recollectors
Municipal ferrous metal recycling, Iron scrap transportation, Scrap metal baling
Metal recycling Ferrous scrap recycling awareness Iron scrap warehousing
Ferrous waste recycling trends, Iron reprocessing and repurposing, Non-ferrous metal recovery
Scrap metal compliance Ferrous material recovery system Iron waste recovery services
Ferrous scrap baling methods, Scrap iron reclamation center, Metal residue utilization
Your posts never fail to enlighten me. Thanks for consistently sharing your knowledge and expertise.
Metal recovery and reclaiming solutions Ferrous waste solutions Iron scrap cutting
Ferrous material handling procedures, Iron scrap reclamation yard, Metal export compliance
Some really nice and utilitarian information on this internet site, likewise I think the layout has excellent features.
Metal waste reduction Ferrous material recycling excellence Iron recycling and recovery facility
Ferrous material company identity, Iron and steel scrap yard, Scrap metal end-of-life management