NSAIDs Double the Risk of Dangerous Blood Clots
Using NSAIDs to manage chronic neck pain could almost double your risk of venous thromboembolism (VTE), including deep venous thrombosis (DVT) and pulmonary embolism, according to new research published in the journal Rheumatology. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a popular prescription and over-the-counter remedy for relief of inflammation and pain but these drugs are far from safe, especially when used for chronic conditions.
The new meta-analysis looked at published observational studies in order to assess the association between NSAID use and these dangerous types of blood clot. Six studies met their inclusion criteria, with 21,401 VTE events assessed. The researchers, working at the Bassett Medical Center and Columbia University College of Physicians and Surgeons, New York City, found that a statistically significantly increased VTE risk among NSAID users and noted that physicians should be aware of this increased risk, especially if prescribing NSAIDs to people whose risk of dangerous blood clotting is already high.
Double the Risk of Potentially Fatal Blood Clots
Venous thromboembolism (VTE) is, thankfully, relatively rare, which is why these researchers had to use observational studies (VTE occurs rarely in clinical trials). They included 1 cohort study involving 19,293 people and 215 VTEs, and 5 case-control studies involving 21,186 cases, along with 110,824 controls. Studies took place in the United Kingdom, France, the Netherlands, Denmark, and Sweden between 2007 and 2013.
Compared to non-users of NSAIDs, users had a 1.8-fold risk of venous thromboembolism. Those using selective cyclooxygenase 2 (COX-2) inhibitors had a 1.99-fold risk. COX-1 inhibitors, like aspirin, have actually been seen to effectively prevent VTE, so the increased risk of this potentially fatal complication likely stems from the use of COX-2 inhibitors.
How COX-2 Inhibitors Work
COX-2 inhibitors prevent the synthesis of prostacyclins but stimulate thromboxane release. Prostacyclins are potent inhibitors of platelet activation and thromboxanes are potent facilitators of platelet aggregation in active platelets.
The potential for adverse events with the use of COX-2 inhibitors has actually been known for many years. In fact, rofecoxib (commonly known as Vioxx) was removed from the market in 2004 because research revealed a significant increase in heart attacks and strokes in those taking this particular NSAID. Other NSAIDs such as celecoxib have since had to display warnings on their labels regarding the risk of stroke and heart attack.
The benefits of COX-2 inhibitors for pain from conditions such as arthritis have been well documented in clinical trials, but the potential doubling of the risk of blood clots may have people with chronic pain conditions thinking twice about using celecoxib and rofecoxib.
Natural Pain Relief
Alternative pain relief options do exist, including natural inhibitors of COX-2 enzymes that do not appear to increase the risk of VTE when taken at their recommended dosage (although further study is certainly warranted to get a clearer picture of this risk).
Such ‘natural NSAIDs’ include:
- Turmeric (or, rather, curcumin, a compound found in turmeric)
- Thunder God Vine
- Omega 3 fatty acids (from fish oil, algal oil and flaxseed oil)
- Resveratrol (a phytochemical found in red grape skins)
- Genistein (an isoflavone found in soybeans)
- Quercetin (found in apples, garlic, onions and other plants)
Excessive consumption of fish (more than 46g a day) does appear to increase the risk of stroke, but at lower doses omega 3 from fish oil actually reduces the risk of stroke while offering relief from pain and inflammation. Curcumin and resveratrol appear to thin the blood and reduce platelet aggregation, thereby reduce the risk of blood clots and stroke. These natural pain relief products could, however, increase the risk of problematic bleeding and should be discontinued at least a week prior to elective surgery.
NSAIDs may remain popular for treating chronic neck pain and other pain conditions but they are typically contraindicated after surgery involving fusion as they can decrease healthy bone growth. They also pose a risk of liver damage and gastrointestinal upset. Anyone using NSAIDs such as celecoxib for chronic neck pain should consult their physician to discuss alternative options if they are concerned about the risk of dangerous blood clots and stroke.
Reference
Ungprasert P, Srivali N, Wijarnpreecha K, Charoenpong P, Knight EL. Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis. Rheumatology (Oxford). 2014 Sep 24. pii: keu408. [Epub ahead of print]
That is a really good tip particularly to those fresh to the blogosphere.
Simple but very precise info… Thank you for sharing this one.
A must read article! aid for ukraine
I think this is among the most significant information for
me. And i am glad reading your article. But wanna remark on some general things,
The website style is wonderful, the articles
is really nice : D. Good job, cheers aid ukraine
https://drwithoutdoctorprescription.site/ canadian pharmacy online
cialis and viagra mix generic version of cialis
canadian drugstore online buy prescription drugs online
https://drwithoutdoctorprescription.site/ ed meds online without prescription or membership
best non prescription ed pills buy prescription drugs from canada
cialis with effexor generic tadalafil 20mg india
viagra without a doctor prescription buy viagra online usa
https://sildenafilmg.shop/# viagra cost
buy real viagra online cheap viagra online
order viagra online viagra amazon
https://sildenafilmg.shop/# cost of viagra
buy real viagra online viagra over the counter walmart
mexican viagra cost of viagra
over the counter viagra order viagra online
viagra for men 100mg viagra
viagra from india sildenafil
buy doxycycline doxycycline nz
how to buy zithromax online zithromax pill
can i buy 40mg doxycycline online doxycycline 150 mg tablets
https://zithromaxforsale.shop/# zithromax capsules 250mg
doxycycline for sale online uk where to buy doxycycline over the counter
amoxicillin 250 mg capsule amoxicillin 500 mg price
https://buylipitor.store/# lipitor tabs
https://buylipitor.store/# lipitor tablets 10mg price
metformin 500 mg without prescription metformin tablets where to buy
https://buytadalafil.men/# buy tadalafil online paypal
https://cipro.best/# buy cipro online canada
diflucan 6 tablets diflucan 100 mg tablet
Лучшие фильмы в жанре боевик на ГидОнлайн..
Фильм смотреть онлайн в хорошем качестве бесплатно фильмы.
Смотреть онлайн фильмы и сериалы
https://gabapentin.icu/# neurontin 800 mg cost
ciprofloxacin 500mg buy online where can i buy cipro online
neurontin 400 mg capsule buy neurontin online
diflucan discount diflucan 200 mg daily
https://withoutprescription.store/# buy canadian drugs
Поиск фильмов, новости кино, отзывы пользователей..
Доступ сматреть кено.
Смотреть фильмы онлайн бесплатно
в хорошем HD.
diflucan 150 mg daily diflucan 150 mg tablet
https://gabapentin.icu/# gabapentin generic
новини київ
magnificent publish, very informative. I’m wondering why the opposite specialists of this sector do not realize this. You must proceed your writing. I am confident, you have a great readers’ base already!
ed treatments buy ed pills
ed meds online without doctor prescription best otc ed pills
https://erectionpills.best/# erectile dysfunction medicines
neurontin 204 neurontin 300 mg coupon
https://erectionpills.best/# new ed treatments
Психолог онлайн. Консультация Когда необходим прием психолога? – 7846 врачей,
7620 отзывов.
Популярные фильмы онлайн..
Здесь Фільм Бетмен (2022) онлайн українською мовою в HD.
У нас Только лучшие Фильмы интернета Бесплатно!
stat
https://doxycyclineonline.store/# buy doxycycline
best pills for ed ed pills for sale
stat
ed meds online without doctor prescription medication for ed dysfunction
doxycycline buy doxycycline
Ukraine
https://drugsonline.store/# erectile dysfunction medication
best ed pills online ed pills for sale
фильмы онлайн смотреть бесплатно
сериалы тут смотреть онлайн
https://edpills.best/# ed pill
ed drug prices pain medications without a prescription
https://doxycyclineonline.store/# doxycycline without prescription
doxycycline doxycycline for sale
natural ed medications non prescription ed pills
руторг новый адрес
stromectol 3 mg tablets price stromectol for humans for sale
https://stromectoltrust.com/# order stromectol over the counter
stromectol 12 mg tablets stromectol 12 mg tablets
stromectol stay active stromectol 3mg tablets
ivermectin dosage for rabbits stromectol tab 3mg
Лучше звоните Солу 5 сезон 9 серия смотреть онлайн
https://stromectoltrust.com/# stromectol 12 mg tablets
cure ed ed tablets
site
https://pharmacyizi.com/# ed drugs over the counter
Мир Дикого Запада 4 Сезон 4 Серия
https://pharmacyizi.com/# cheap erectile dysfunction pills
смотреть в хорошем качестве
site
https://pharmacyizi.com/# cheap ed drugs
https://pharmacyizi.com/# drugs online
pills for erection what causes ed
buy generic ed pills online treatment for erectile dysfunction
https://pharmacyizi.com/# best ed solution
https://pharmacyizi.com/# impotence pills
https://pharmacyizi.com/# best ed drugs
best ed medication ed drugs online from canada
https://pharmacyizi.com/# ed remedies
смотреть художественные фильмы
https://pharmacyizi.com/# ed natural treatment
best ed medicine natural herbs for ed
discount prescription drugs buy prescription drugs from canada cheap
https://allpharm.store/# Pamelor
тв фильмы
buying ed pills online ed drugs list
https://onlinepharmacy.men/# online pharmacy meds
Keflex Dostinex
medstore online pharmacy good pill pharmacy
https://erectionpills.shop/# medication for ed
new ed treatments medication for ed
Под напряжением 23 серия смотреть новинки фильмов в HD онлайн
ed treatment drugs drugs for ed
Тобол 2022 смотреть онлайн в хорошем качестве
https://allpharm.store/# canada online pharmacies
men’s ed pills п»їerectile dysfunction medication
Aurogra rx pharmacy
meds online without doctor prescription prescription drugs online
https://erectionpills.shop/# ed pills comparison
legitimate canadian pharmacy online reliable canadian pharmacy
Biaxin Top Avana
https://canadiandrugs.best/# canadian drug prices
https://canadiandrugs.best/# cvs prescription prices without insurance
https://stromectolbestprice.com/# how much ivermectin to give a dog
stromectol tablets buy online stromectol covid
is ivomec the same as ivermectin ivermectin for hookworm in humans
https://stromectolbestprice.com/# ivermectin pills for lice
stromectol tablets stromectol purchase
http://stromectolbestprice.com/# topical ivermectin for cats
site
https://drugsbestprice.com/# treat ed
buy prescription drugs without doctor buy erection pills
https://drugsbestprice.com/# herbal ed
Хатико Самый верный друг смотреть фильмы онлайн
https://medrxfast.com/# ed meds online without doctor prescription
best canadian online pharmacy prescription drugs
buy cheap prescription drugs online meds online without doctor prescription
https://medrxfast.com/# meds online without doctor prescription
prescription drugs without prior prescription carprofen without vet prescription
site
https://medrxfast.com/# buy prescription drugs without doctor
site
https://medrxfast.com/# prescription drugs without doctor approval
cat antibiotics without pet prescription buy prescription drugs online legally
https://medrxfast.com/# buy prescription drugs from canada cheap
https://medrxfast.com/# best online canadian pharmacy
best non prescription ed pills buy prescription drugs from canada cheap
https://medrxfast.com/# ed meds online without prescription or membership
https://medrxfast.com/# legal to buy prescription drugs from canada
https://medrxfast.com/# buy prescription drugs from canada
https://medrxfast.com/# canadian drugstore online
https://medrxfast.com/# meds online without doctor prescription
site
https://medrxfast.com/# canadian online drugstore
https://gabapentin.top/# 600 mg neurontin tablets
https://diflucan.life/# diflucan 150 mg fluconazole
site
https://gabapentin.top/# neurontin brand name
вусик джошуа коли бій 2022
https://diflucan.life/# how to buy diflucan
https://diflucan.life/# canadian order diflucan online
https://valtrex.icu/# buy valtrex generic online
воскресный вечер с владимиром соловьевым смотреть бесплатно последний выпуск вчера онлайн на ютубе
Дім дракона дивитись онлайн
https://paxil.tech/# paxil for bipolar
https://glucophage.top/# metformin order canada
воскресный вечер с владимиром соловьевым последний выпуск сегодня
https://deltasone.icu/# purchase prednisone no prescription
https://deltasone.icu/# 5 mg prednisone daily
https://deltasone.icu/# prednisone 15 mg daily
https://glucophage.top/# metformin glucophage xr
https://deltasone.icu/# brand prednisone
order prednisone 10 mg tablet prednisone uk over the counter
https://deltasone.icu/# generic prednisone 10mg
I discovered your blog site on google and check a few of your early posts. Continue to keep up the very good operate. I just additional up your RSS feed to my MSN News Reader. Seeking forward to reading more from you later on!…
It’s very interesting! If you need help, look here: hitman agency
Thank you for great information. look forward to the continuation. – womens hey dudes
Scrap metal grading standards Ferrous metal market dynamics Iron scrap recollectors
Municipal ferrous metal recycling, Iron scrap transportation, Scrap metal baling
Metal recycling Ferrous scrap recycling awareness Iron scrap warehousing
Ferrous waste recycling trends, Iron reprocessing and repurposing, Non-ferrous metal recovery
Scrap metal compliance Ferrous material recovery system Iron waste recovery services
Ferrous scrap baling methods, Scrap iron reclamation center, Metal residue utilization
Your posts never fail to enlighten me. Thanks for consistently sharing your knowledge and expertise.
Metal recovery and reclaiming solutions Ferrous waste solutions Iron scrap cutting
Ferrous material handling procedures, Iron scrap reclamation yard, Metal export compliance
Some really nice and utilitarian information on this internet site, likewise I think the layout has excellent features.
Metal waste reduction Ferrous material recycling excellence Iron recycling and recovery facility
Ferrous material company identity, Iron and steel scrap yard, Scrap metal end-of-life management
Hey There. I found your blog using msn. This is an extremely well written article. I will be sure to bookmark it and come back to read more of your useful information. Thanks for the post. I will definitely comeback.
obviously like your web site but you need to check the spelling on quite a few of your posts. Several of them are rife with spelling problems and I find it very bothersome to tell the truth nevertheless I will surely come back again.
In our online publication, we exert oneself to be your secure start in search the latest scuttlebutt nearly media personalities in Africa. We settle staunch notoriety to promptly covering the most relevant events with regard to well-known figures on this continent.
Africa is rich in talents and solitary voices that make the cultural and sexual landscape of the continent. We focus not only on celebrities and showbiz stars but also on those who compel significant contributions in numerous fields, be it art, civil affairs, art, or philanthropy https://afriquestories.com/controverse-l-ex-compagne-de-larry-bourgeois/
Our articles fix up with provision readers with a thorough overview of what is incident in the lives of media personalities in Africa: from the latest news and events to analyzing their ascendancy on society. We control track of actors, musicians, politicians, athletes, and other celebrities to demand you with the freshest information firsthand.
Whether it’s an exclusive talk with with a revered celeb, an investigation into scandalous events, or a look at of the latest trends in the African showbiz humanity, we utmost to be your fundamental authority of dirt back media personalities in Africa. Subscribe to our hand-out to stay informed back the hottest events and engrossing stories from this captivating continent.
Wow, awesome blog layout! How lengthy have you ever been running a blog for? you make running a blog glance easy. The entire look of your site is fantastic, as smartly as the content!
Thank you so much for giving everyone an exceptionally remarkable chance to read in detail from here. It’s usually very pleasing plus packed with a great time for me personally and my office mates to visit the blog at the very least thrice every week to find out the new secrets you have got. And indeed, I’m just always motivated with your unbelievable solutions you give. Selected 2 areas in this post are undoubtedly the most suitable I have had.
Salutation to our dedicated stand for staying informed less the latest news from the Agreed Kingdom. We take cognizance of the import of being well-informed upon the happenings in the UK, whether you’re a dweller, an expatriate, or unaffectedly interested in British affairs. Our exhaustive coverage spans across sundry domains including diplomacy, conservation, savoir vivre, extravaganza, sports, and more.
In the jurisdiction of wirepulling, we keep you updated on the intricacies of Westminster, covering according to roberts rules of order debates, sway policies, and the ever-evolving prospect of British politics. From Brexit negotiations and their import on pursuit and immigration to native policies affecting healthcare, edification, and the atmosphere, we victual insightful review and timely updates to help you manoeuvre the complex sphere of British governance – https://newstopukcom.com/papa-roach-o2-academy-december-2nd/.
Profitable news is crucial against sagacity the pecuniary pulsation of the nation. Our coverage includes reports on supermarket trends, organization developments, and profitable indicators, donation valuable insights after investors, entrepreneurs, and consumers alike. Whether it’s the latest GDP figures, unemployment rates, or corporate mergers and acquisitions, we strive to deliver meticulous and applicable message to our readers.
Hello there! Do you know if they make any plugins to help with SEO?
I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good gains.
If you know of any please share. Many thanks!
You can read similar art here: Ecommerce
Great site. A lot of useful information here. I am sending it to a few buddies ans also sharing in delicious. And of course, thank you to your sweat!
Welcome to our dedicated platform in return staying briefed round the latest news from the Collective Kingdom. We understand the importance of being learned about the happenings in the UK, whether you’re a resident, an expatriate, or unaffectedly interested in British affairs. Our encyclopaedic coverage spans across diversified domains including wirepulling, concision, education, entertainment, sports, and more.
In the kingdom of wirepulling, we living you updated on the intricacies of Westminster, covering parliamentary debates, government policies, and the ever-evolving countryside of British politics. From Brexit negotiations and their burden on trade and immigration to residential policies affecting healthcare, education, and the circumstances, we cater insightful analysis and punctual updates to refrain from you manoeuvre the complex society of British governance – https://newstopukcom.com/self-esteem-inspires-with-commencement-speech/.
Monetary despatch is crucial for sagacity the fiscal pulsation of the nation. Our coverage includes reports on superstore trends, organization developments, and profitable indicators, contribution valuable insights in behalf of investors, entrepreneurs, and consumers alike. Whether it’s the latest GDP figures, unemployment rates, or corporate mergers and acquisitions, we strive to convey accurate and akin message to our readers.
The core of your writing while appearing reasonable initially, did not really work perfectly with me personally after some time. Someplace within the paragraphs you managed to make me a believer but just for a very short while. I nevertheless have a problem with your jumps in logic and one would do well to help fill in all those breaks. In the event you actually can accomplish that, I could certainly end up being amazed.
Some truly quality posts on this website , saved to favorites.
Hi there, this weekend is fastidious in support of me, because this occasion i
am reading this impressive educational piece of writing
here at my residence.
I¦ve recently started a blog, the info you provide on this site has helped me greatly. Thanks for all of your time & work.
It’s a game. Five dollars is free. Try it It’s not an easy game
->-> 바카라사이트.COM
Heya i’m for the first time here. I came across this board and I find It truly useful & it helped me out a lot. I hope to give something back and help others like you helped me.
Hello! This is kind of off topic but I need some help from an established blog. Is it very difficult to set up your own blog? I’m not very techincal but I can figure things out pretty fast. I’m thinking about setting up my own but I’m not sure where to start. Do you have any points or suggestions? Cheers
Some genuinely nice and useful information on this internet site, as well I believe the style holds excellent features.
You have noted very interesting details! ps decent web site.
Wow, incredible blog format! How long have you been running
a blog for? you make blogging glance easy. The whole look of your site is fantastic, let alone the
content material! You can see similar here sklep internetowy
Hello! Do you know if they make any plugins to protect against hackers? I’m kinda paranoid about losing everything I’ve worked hard on. Any suggestions?
What i do not realize is in fact how you are no longer actually a lot more well-appreciated than you might be right now. You are so intelligent. You realize therefore considerably on the subject of this subject, produced me in my opinion consider it from numerous numerous angles. Its like men and women aren’t involved except it¦s one thing to do with Woman gaga! Your personal stuffs nice. Always handle it up!
You should take part in a contest for one of the best blogs on the web. I will recommend this site!
Good post. I certainly love this website. Keep writing!
Hmm it seems like your site ate my first comment (it was extremely long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog. I as well am an aspiring blog blogger but I’m still new to the whole thing. Do you have any points for rookie blog writers? I’d genuinely appreciate it.
Quality posts is the main to be a focus for the viewers to visit the website, that’s what this website is providing.
I enjoy what you guys are usually up too. Such clever work and exposure! Keep up the very good works guys I’ve added you guys to blogroll.
I really like what you guys are up too. This sort of clever work and coverage! Keep up the fantastic works guys I’ve added you guys to my blogroll.
Your style is so unique compared to other people I have read stuff from. Thank you for posting when you have the opportunity, Guess I will just bookmark this web site.
We are a group of volunteers and starting a new scheme in our community. Your site provided us with valuable information to work on. You have done an impressive job and our whole community will be grateful to you.
It’s a game. Five dollars is free. Try it It’s not an easy game
->-> 토토사이트 .COM
What’s Taking place i’m new to this, I stumbled upon this I’ve discovered It absolutely helpful and it has aided me out loads. I hope to give a contribution & aid different customers like its aided me. Great job.
hello!,I like your writing very so much! proportion we keep up a correspondence extra approximately your article on AOL? I need a specialist on this area to unravel my problem. Maybe that’s you! Having a look forward to see you.