Once-Daily Rheumatoid Arthritis Pill Shows Promise

rheumatoid arthritis baricitinib EULAR 2012 congress

Ed Keystone, MD, of the University of Toronto, presented preliminary findings from a trial of a one-a-day Rheumatoid Arthritis medication, baricitinib.

A new, once-daily Rheumatoid Arthritis pill looks set to revolutionize treatment of the autoimmune joint disease as trial data is released for Baricitinib. Last month the FDA approved a twice-daily drug for RA called tofacitinib and some rheumatologists are singing the praises of this latest move towards the ‘holy grail’ of RA treatment, the one-a-day oral medication. Rheumatoid Arthritis, which can cause symptoms of fatigue, fever, joint swelling, and neck pain, is thought to affect 1.3 million people in the US, with three times more women than men affected.

Patients currently have a range of biologics, anti-inflammatories, and immunosuppressants available to control and manage symptoms, such as neck pain, of the autoimmune joint disease. However, drugs such as Humira, Orencia, and NSAIDs, do not work for some patients, or cause intolerable side-effects, making news of a new RA medication extremely welcome for those suffering chronic pain.

New Drugs for Rheumatoid Arthritis

Presenting the findings of a Phase IIb trial at the European League Against Rheumatism (EULAR) Congress 2012, lead author Edward Keystone, MD, noted that there were significant differences in response compared to placebo just two weeks into the trial with baricitinib. The medication is being investigated by Eli Lilly & Co and Incyte Corp and is a JAK1/JAK2 inhibitor like Pfizer’s tofacitinib. What this means is that it works differently to medications such as methotrexate, oral steroids, NSAIDs, and biologics and is being viewed as something of a shift in the paradigm for treating Rheumatoid Arthritis. A particular benefit of this new type of drug is that it is cheaper to manufacture than other RA medications.


Significant RA Symptom Improvement with Baricitinib

In this study, which included 301 patients with active RA on a stable dose of methotrexate, baricitinib was given in doses of 1mg, 2mg, 4mg, and 8mg once daily, with a control group given a placebo instead. In the groups taking the 4mg and 8mg dose of baricitinib, 76% achieved the primary outcome of the study, which was a 20% improvement in joint swelling at twelve weeks according to the American College of Rheumatology 20 (ACR20). In the placebo group, 41% of the patients achieved this response, making the difference statistically significant in favor of baricitinib.

RA Symptoms Reduced by One-A-Day Pill

Other factors assessed in the study included secondary endpoints of ACR50 and ACR70, with 35% of those taking 4mg daily, and 40% of those taking 8mg daily achieving a 50% improvement in joint swelling (vs. 10% of the placebo group). A 70% improvement in RA joint swelling was seen in 23% of the 4mg group and 30% of the 8mg compared to 2% of the placebo group in the trial.

rheumatoid arthritis jak1 jak 2 pathway medication target

The JAK1/JAK2 signalling pathway is the target of these new RA medications.

Side-Effects of Baricitinib

Adverse events associated with baricitinib were experienced by some patients, with infections being the most common. However, differences between placebo and treatment groups were minimal in this regard, with 12% of the controls suffering infections and 14% of the baricitinib group developing infections during the trials. No deaths occurred in the active treatment groups, although seven serious adverse events were reported in six patients: two in the placebo group, four in the 2mg group, and one in the 8mg group.

The Future of Rheumatoid Arthritis Treatment

A large number of patients with Rheumatoid Arthritis are unresponsive to currently available treatments and so these new drugs, working on inhibiting the important JAK1/JAK2 signalling pathway, could represent a viable choice for such patients. More research needs doing to determine the efficacy and safety of these new types of medication for RA, and patients responding well to current treatments such as methotrexate are unlikely to be switched to these new drugs even if approved. Although the study’s authors are wary of comparing baricitinib to tofacitinib they did note that side-effects and efficacy appear similar, with baricitinib offering the added advantage of being a one-a-day pill for Rheumatoid Arthritis.

Reference


European League Against Rheumatism (EULAR) Congress 2012. Abstract #LB0005. Presented June 8, 2012.

741 replies
  1. marizonilogert
    marizonilogert says:

    Hi, I think your site might be having browser compatibility issues. When I look at your website in Safari, it looks fine but when opening in Internet Explorer, it has some overlapping. I just wanted to give you a quick heads up! Other then that, fantastic blog!

    Reply
  2. Berita terkini detik hari ini
    Berita terkini detik hari ini says:

    Attractive component to content. I just stumbled upon your site and in accession capital to assert that I get actually loved account your weblog posts. Anyway I will be subscribing in your augment or even I success you get entry to constantly quickly.

    Reply
  3. jaqueta yeezy
    jaqueta yeezy says:

    The next time I read a blog, I hope that it doesnt disappoint me as much as this one. I mean, I know it was my choice to read, but I actually thought youd have something interesting to say. All I hear is a bunch of whining about something that you could fix if you werent too busy looking for attention.

    Reply
  4. slot hoki terbesar
    slot hoki terbesar says:

    Do you mind if I quote a few of your posts as long as I provide credit and sources back to your blog? My website is in the exact same niche as yours and my visitors would certainly benefit from a lot of the information you present here. Please let me know if this alright with you. Thank you!

    Reply
  5. bromo package tour
    bromo package tour says:

    Have you ever considered writing an ebook or guest authoring on other websites? I have a blog based on the same ideas you discuss and would really like to have you share some stories/information. I know my subscribers would enjoy your work. If you are even remotely interested, feel free to send me an email.

    Reply
  6. slot gacor
    slot gacor says:

    You actually make it seem so easy with your presentation however I in finding this topic to be really something which I feel I would never understand. It sort of feels too complex and very vast for me. I’m having a look forward for your subsequent publish, I?¦ll try to get the hang of it!

    Reply
  7. hire a hacker for discord
    hire a hacker for discord says:

    Its like you read my mind! You seem to know so much about this, like you wrote the book in it or something. I think that you can do with some pics to drive the message home a little bit, but other than that, this is magnificent blog. A great read. I will definitely be back.

    Reply
  8. slot hoki asia
    slot hoki asia says:

    I just couldn’t go away your website prior to suggesting that I extremely enjoyed the usual info a person supply in your guests? Is going to be back regularly in order to check out new posts.

    Reply
  9. lavar uniformes
    lavar uniformes says:

    I like what you guys are up also. Such intelligent work and reporting! Carry on the excellent works guys I have incorporated you guys to my blogroll. I think it will improve the value of my web site 🙂

    Reply
  10. organic potassium suppliers in indonesia
    organic potassium suppliers in indonesia says:

    I know this if off topic but I’m looking into starting my own blog and was wondering what all is required to get setup? I’m assuming having a blog like yours would cost a pretty penny? I’m not very internet savvy so I’m not 100 sure. Any suggestions or advice would be greatly appreciated. Appreciate it

    Reply
  11. xoyxoy.com
    xoyxoy.com says:

    I think other web-site proprietors should take this web site as an model, very clean and great user genial style and design, as well as the content. You are an expert in this topic!

    Reply
  12. Slot Gacor 777
    Slot Gacor 777 says:

    You could certainly see your skills in the work you write. The arena hopes for even more passionate writers like you who aren’t afraid to say how they believe. All the time follow your heart.

    Reply
  13. pragmatic play
    pragmatic play says:

    An interesting discussion is worth comment. I think that you should write more on this topic, it might not be a taboo subject but generally people are not enough to speak on such topics. To the next. Cheers

    Reply
  14. cara menyadap wa tanpa brandcode
    cara menyadap wa tanpa brandcode says:

    You actually make it seem so easy together with your presentation however I find this matter to be really one thing that I think I might by no means understand. It kind of feels too complicated and extremely broad for me. I am taking a look ahead in your next post, I will attempt to get the grasp of it!

    Reply
  15. kbc lottery 2023
    kbc lottery 2023 says:

    Attractive section of content. I just stumbled upon your site and in accession capital to assert that I acquire in fact enjoyed account your blog posts. Anyway I’ll be subscribing to your feeds and even I achievement you access consistently fast.

    Reply
  16. Kuburan Agama buddha
    Kuburan Agama buddha says:

    certainly like your website but you have to take a look at the spelling on several of your posts. Several of them are rife with spelling problems and I to find it very bothersome to tell the reality nevertheless I will certainly come back again.

    Reply
  17. henki hariadi
    henki hariadi says:

    Great ?V I should certainly pronounce, impressed with your web site. I had no trouble navigating through all the tabs and related information ended up being truly easy to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, web site theme . a tones way for your customer to communicate. Nice task..

    Reply
  18. Rental mobil batam
    Rental mobil batam says:

    Wonderful beat ! I would like to apprentice at the same time as you amend your website, how can i subscribe for a blog web site? The account helped me a acceptable deal. I have been tiny bit familiar of this your broadcast offered bright clear idea

    Reply
  19. henki hariadi
    henki hariadi says:

    Thanks for sharing superb informations. Your web site is very cool. I am impressed by the details that you have on this website. It reveals how nicely you understand this subject. Bookmarked this website page, will come back for extra articles. You, my friend, ROCK! I found just the info I already searched everywhere and just couldn’t come across. What a great website.

    Reply
  20. desentupidora em vitoria
    desentupidora em vitoria says:

    Hi there, just became alert to your blog through Google, and found that it is truly informative. I am going to watch out for brussels. I’ll be grateful if you continue this in future. Numerous people will be benefited from your writing. Cheers!

    Reply
  21. henki hariadi
    henki hariadi says:

    Hmm is anyone else experiencing problems with the images on this blog loading? I’m trying to determine if its a problem on my end or if it’s the blog. Any feed-back would be greatly appreciated.

    Reply
  22. slot online
    slot online says:

    obviously like your web site however you have to test the spelling on quite a few of your posts. Several of them are rife with spelling problems and I to find it very troublesome to tell the truth nevertheless I¦ll definitely come again again.

    Reply
  23. politeknik negeri lampung
    politeknik negeri lampung says:

    Greetings from Idaho! I’m bored to death at work so I decided to check out your website on my iphone during lunch break. I enjoy the information you present here and can’t wait to take a look when I get home. I’m shocked at how fast your blog loaded on my phone .. I’m not even using WIFI, just 3G .. Anyways, amazing blog!

    Reply
  24. henki hariadi
    henki hariadi says:

    I really enjoy reading through on this internet site, it contains good articles. “Don’t put too fine a point to your wit for fear it should get blunted.” by Miguel de Cervantes.

    Reply
  25. henki hariadi
    henki hariadi says:

    Undeniably believe that which you said. Your favorite reason seemed to be on the net the simplest thing to be aware of. I say to you, I certainly get irked while people think about worries that they plainly don’t know about. You managed to hit the nail upon the top and defined out the whole thing without having side effect , people could take a signal. Will probably be back to get more. Thanks

    Reply
  26. situs judi slot
    situs judi slot says:

    That is the best blog for anybody who desires to search out out about this topic. You notice so much its nearly laborious to argue with you (not that I truly would need…HaHa). You definitely put a new spin on a topic thats been written about for years. Nice stuff, just great!

    Reply
  27. holiday sao paulo
    holiday sao paulo says:

    I will right away take hold of your rss feed as I can’t in finding your e-mail subscription link or newsletter service. Do you’ve any? Please let me realize in order that I may subscribe. Thanks.

    Reply
  28. slot online
    slot online says:

    Hey There. I found your blog the usage of msn. That is a really neatly written article. I will make sure to bookmark it and come back to read more of your helpful information. Thank you for the post. I’ll certainly return.

    Reply
  29. Panen88
    Panen88 says:

    I’ve been absent for some time, but now I remember why I used to love this site. Thanks, I will try and check back more frequently. How frequently you update your site?

    Reply
  30. ทางเข้าpg slot มือถือ
    ทางเข้าpg slot มือถือ says:

    Thank you for sharing superb informations. Your website is very cool. I’m impressed by the details that you have on this website. It reveals how nicely you perceive this subject. Bookmarked this web page, will come back for extra articles. You, my friend, ROCK! I found simply the information I already searched all over the place and just couldn’t come across. What a great site.

    Reply
  31. febracis cursos online
    febracis cursos online says:

    Thanks for the sensible critique. Me & my neighbor were just preparing to do some research about this. We got a grab a book from our area library but I think I learned more clear from this post. I’m very glad to see such magnificent information being shared freely out there.

    Reply
  32. bitcoin hacker software
    bitcoin hacker software says:

    Hi there! I could have sworn I’ve been to this website before but after browsing through some of the post I realized it’s new to me. Anyhow, I’m definitely happy I found it and I’ll be book-marking and checking back frequently!

    Reply
  33. paineis solares em franca sp
    paineis solares em franca sp says:

    You actually make it seem so easy together with your presentation but I in finding this topic to be actually one thing that I feel I might never understand. It seems too complex and extremely large for me. I am having a look forward to your next publish, I will attempt to get the dangle of it!

    Reply
  34. coach
    coach says:

    I have been browsing online more than 3 hours today, yet I never found any interesting article like yours. It is pretty worth enough for me. Personally, if all website owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.

    Reply
  35. kbc lottery 2023
    kbc lottery 2023 says:

    What i don’t understood is if truth be told how you’re no longer actually a lot more smartly-appreciated than you might be right now. You’re very intelligent. You understand therefore considerably on the subject of this matter, made me personally imagine it from numerous varied angles. Its like women and men don’t seem to be involved except it is something to do with Lady gaga! Your individual stuffs nice. All the time deal with it up!

    Reply
  36. pensiuni crisan
    pensiuni crisan says:

    I have been exploring for a bit for any high quality articles or weblog posts on this sort of space . Exploring in Yahoo I at last stumbled upon this web site. Studying this information So i’m glad to express that I have a very just right uncanny feeling I found out just what I needed. I so much surely will make certain to don’t put out of your mind this web site and give it a look regularly.

    Reply
  37. översättning
    översättning says:

    Please let me know if you’re looking for a article author for your weblog. You have some really good posts and I believe I would be a good asset. If you ever want to take some of the load off, I’d really like to write some articles for your blog in exchange for a link back to mine. Please blast me an email if interested. Regards!

    Reply
  38. tax accounting
    tax accounting says:

    An impressive share, I just given this onto a colleague who was doing a little analysis on this. And he in fact bought me breakfast because I found it for him.. smile. So let me reword that: Thnx for the treat! But yeah Thnkx for spending the time to discuss this, I feel strongly about it and love reading more on this topic. If possible, as you become expertise, would you mind updating your blog with more details? It is highly helpful for me. Big thumb up for this blog post!

    Reply
  39. suzuki surabaya
    suzuki surabaya says:

    I have been browsing on-line greater than three hours today, yet I by no means discovered any fascinating article like yours. It is pretty value enough for me. Personally, if all site owners and bloggers made excellent content material as you did, the internet will likely be a lot more useful than ever before.

    Reply
  40. Dubbing Vendor
    Dubbing Vendor says:

    Wonderful goods from you, man. I’ve understand your stuff previous to and you’re just too fantastic. I really like what you have acquired here, certainly like what you are stating and the way in which you say it. You make it enjoyable and you still care for to keep it sensible. I can not wait to read far more from you. This is actually a wonderful site.

    Reply
  41. Sewa motor belitung
    Sewa motor belitung says:

    Hi there! Do you know if they make any plugins to help with Search Engine Optimization? I’m trying to get my blog to rank for some targeted keywords but I’m not seeing very good gains. If you know of any please share. Kudos!

    Reply
  42. kuliner jakarta selatan
    kuliner jakarta selatan says:

    I know this if off topic but I’m looking into starting my own blog and was wondering what all is needed to get set up? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web savvy so I’m not 100 certain. Any suggestions or advice would be greatly appreciated. Appreciate it

    Reply
  43. Rental mobil belitung
    Rental mobil belitung says:

    Hey there! This is my first visit to your blog! We are a team of volunteers and starting a new initiative in a community in the same niche. Your blog provided us valuable information to work on. You have done a wonderful job!

    Reply
  44. deposit pulsa
    deposit pulsa says:

    Please let me know if you’re looking for a article author for your weblog. You have some really great posts and I believe I would be a good asset. If you ever want to take some of the load off, I’d really like to write some articles for your blog in exchange for a link back to mine. Please blast me an e-mail if interested. Thank you!

    Reply
  45. cell phone hackers for hire
    cell phone hackers for hire says:

    Do you mind if I quote a few of your posts as long as I provide credit and sources back to your website? My blog is in the exact same area of interest as yours and my visitors would truly benefit from a lot of the information you present here. Please let me know if this alright with you. Regards!

    Reply
  46. jackpot168
    jackpot168 says:

    I have been absent for a while, but now I remember why I used to love this web site. Thank you, I¦ll try and check back more frequently. How frequently you update your web site?

    Reply
  47. Rajawin88
    Rajawin88 says:

    Excellent weblog right here! Also your site lots up fast! What web host are you using? Can I get your affiliate link to your host? I want my site loaded up as quickly as yours lol

    Reply
  48. discord hackers for hire
    discord hackers for hire says:

    Just desire to say your article is as surprising. The clearness for your post is simply excellent and i could suppose you are a professional in this subject. Fine together with your permission allow me to clutch your feed to stay up to date with approaching post. Thank you a million and please continue the enjoyable work.

    Reply
  49. upnvjatim
    upnvjatim says:

    I will right away grasp your rss as I can not to find your e-mail subscription link or e-newsletter service. Do you have any? Please allow me understand so that I may subscribe. Thanks.

    Reply
  50. Comprar banderas
    Comprar banderas says:

    Can I simply say what a reduction to seek out someone who really is aware of what theyre talking about on the internet. You positively know how one can convey a difficulty to mild and make it important. More individuals must read this and understand this aspect of the story. I cant believe youre not more common because you undoubtedly have the gift.

    Reply
  51. Amarração amorosa
    Amarração amorosa says:

    After study a few of the blog posts on your website now, and I truly like your way of blogging. I bookmarked it to my bookmark website list and will be checking back soon. Pls check out my web site as well and let me know what you think.

    Reply
  52. Promo deposit 25k
    Promo deposit 25k says:

    I’ve been exploring for a bit for any high quality articles or blog posts on this sort of area . Exploring in Yahoo I at last stumbled upon this site. Reading this information So i am happy to convey that I’ve a very good uncanny feeling I discovered exactly what I needed. I most certainly will make certain to don’t forget this site and give it a look on a constant basis.

    Reply
  53. astrosiva
    astrosiva says:

    This blog is definitely rather handy since I’m at the moment creating an internet floral website – although I am only starting out therefore it’s really fairly small, nothing like this site. Can link to a few of the posts here as they are quite. Thanks much. Zoey Olsen

    Reply
  54. pothunalam
    pothunalam says:

    I wish to voice my passion for your generosity in support of men who have the need for assistance with your study. Your special dedication to passing the solution up and down was rather functional and have consistently encouraged guys and women like me to achieve their endeavors. Your insightful key points entails so much a person like me and somewhat more to my mates. Thank you; from all of us.

    Reply
  55. sparepart komatsu
    sparepart komatsu says:

    What i do not understood is actually how you’re not actually much more well-liked than you may be now. You’re so intelligent. You realize therefore significantly relating to this subject, produced me personally consider it from so many varied angles. Its like men and women aren’t fascinated unless it is one thing to do with Lady gaga! Your own stuffs great. Always maintain it up!

    Reply
  56. Vibrador Joanna
    Vibrador Joanna says:

    Hi there! This is kind of off topic but I need some guidance from an established blog. Is it difficult to set up your own blog? I’m not very techincal but I can figure things out pretty fast. I’m thinking about creating my own but I’m not sure where to begin. Do you have any points or suggestions? Thank you

    Reply
  57. Gokong77
    Gokong77 says:

    I think this is among the most significant information for me. And i am glad reading your article. But should remark on few general things, The website style is perfect, the articles is really great : D. Good job, cheers

    Reply
  58. Sbobet138
    Sbobet138 says:

    I know this if off topic but I’m looking into starting my own weblog and was wondering what all is required to get setup? I’m assuming having a blog like yours would cost a pretty penny? I’m not very web smart so I’m not 100 sure. Any tips or advice would be greatly appreciated. Thanks

    Reply
  59. Bonanza123
    Bonanza123 says:

    naturally like your web-site however you need to take a look at the spelling on several of your posts. A number of them are rife with spelling problems and I to find it very troublesome to tell the truth on the other hand I will definitely come again again.

    Reply
  60. series online
    series online says:

    obviously like your web site however you have to check the spelling on quite a few of your posts. A number of them are rife with spelling issues and I find it very bothersome to tell the reality however I will definitely come back again.

    Reply
  61. Roket88
    Roket88 says:

    I¦ll immediately take hold of your rss feed as I can not to find your email subscription hyperlink or newsletter service. Do you have any? Kindly permit me understand so that I may subscribe. Thanks.

    Reply
  62. Elang88
    Elang88 says:

    Admiring the dedication you put into your website and detailed information you offer. It’s great to come across a blog every once in a while that isn’t the same unwanted rehashed information. Fantastic read! I’ve saved your site and I’m including your RSS feeds to my Google account.

    Reply
  63. Cameronnig
    Cameronnig says: